• Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
          • Cysto, L RPG, L Stent
          • Cysto, R Stent w/o RPG
          • Cysto, R RPG, R Stent
        • Cysto, bladder biopsy
        • Cysto and TRUS Prostate Biopsy (OR)
        • Cysto Botox (F)
        • Individual parts of cystos
      • Prostate Biopsy >
        • Cysto and TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (office)
        • MRI Fusion TRUS Prostate Biopsy
      • Robot Left Radical Nephrectomy
      • Robot Right Radical Nephrectomy
      • Robot Radical Prostatectomy w/ PLND
      • TURBT (M)
      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
        • Left Proximal ESWL
        • Left Renal ESWL
        • Right Proximal ESWL
        • Right Renal ESWL
      • TURP
      • Vasectomy
    • Plans >
      • Erectile Dysfunction
      • NMIBC
      • Peyronie's Disease
      • Prostate Cancer
    • Medications >
      • Antibiotics >
        • Bactrim
        • Cephalosporins >
          • Keflex
        • Ciprofloxacin
        • Macrobid
        • Gentamicin
      • Medications and Dialysis
      • Anticoagulation and Antiplatelets
      • 5α-Reductase Inhibitors
      • PDE5i
      • Prostate Cancer Drugs >
        • Abiraterone
        • Androgen Receptor Blockers
        • Pembrolizumab
      • Anticholinergics & β-3 Agonists
      • Estrace
    • Patient Discussions >
      • Prostate Cancer
      • PSA Screening
      • Tobacco Cessation
    • Radiation Exposure
    • Medicolegal
    • Urology Jokes & Quotes
  • Subjects
    • Various Pathology >
      • Neurogenic Bladder/Spinal Cord Injury
      • CKD/ESRD
      • Erectile Dysfunction >
        • IPP
      • Female Urology
      • Hypogonadism
      • Imaging
      • Nocturia
      • Overactive Bladder
      • Trauma
      • Urine Retention
    • Urologic Malignancy >
      • Prostate Cancer >
        • Choosing Therapy
        • Imaging
        • Genomic Testing
        • Locally Advanced and BCR
        • Metastatic Prostate Cancer
        • ADT and Hormonal Therapy
        • Surgery
        • Radiation
        • Adjuvant & Salvage Therapy
        • Prostate Biopsy
        • Studies >
          • Landmark Studies
          • Research
      • Bladder Cancer >
        • MIBC
        • NMIBC >
          • Intravesical Therapy
        • Urine Markers
        • Chemotherapy
        • Metastatic Bladder Cancer
        • Immunotherapy
        • Cystectomy & PLND
        • Variant Histology
        • Trimodal Therapy
        • Post Cystectomy Care (ERAS)
        • Studies
      • Renal Cancer >
        • Work-up
        • Treatment
        • Surgery
        • Renal Cysts
        • Locally Advanced & Metastatic
        • RCC Surveillance
        • Calculators & Nomograms
        • Landmark Studies
        • Other Studies
      • Upper Tract UCC >
        • Laser Treatment >
          • Studies
        • UTUC Chemotherapy
        • Surgery
        • Landmark Studies
      • Testicular Cancer >
        • Evaluation
        • Treatment
        • Surveillance
        • Landmark Studies
      • Penile Cancer
      • Urethral Cancer
      • Adrenal Lesions
    • Stones >
      • Studies
      • Evaluation
      • Treatment (Non Surgical)
      • Surgical Treatment
    • BPH >
      • TURP
      • Urolift
      • Surgical Therapies
      • IPSS
    • Fertility >
      • Imaging and Lab Tests
      • Work-up
      • Surgery
      • Infertility in Spinal Cord Injury
      • Study guide
      • Interventions
      • Studies
    • Infection >
      • Fournier's Gangrene
      • Orchitis
      • UTI
      • Recurrent UTI
    • Incontinence >
      • Artificial Urethral Sphincter
      • Neuromodulation
      • Slings
      • Urethral Bulking
    • Pediatric Urology >
      • Pediatric Infections
      • Pediatric Surgery
      • Pediatric Tumors
      • Pediatric Trauma
    • Reconstruction >
      • Ureteral Stricture
      • Urethral Stricture
      • Studies
    • Other Random Studies >
      • Blood Transfusions
      • Fistula
      • Other studies/notes
  • Procedures
    • Cystectomy
    • Incisions
    • Endoscopic >
      • Cystoscopy
      • Ureteroscopy
      • Ureteral Stenting
    • Female Surgery >
      • Interstim & PTNS
      • Midurethral Sling
      • Sacrocolpopexy
    • Nephrectomy
    • PCNL
    • Prostate Biopsy
    • Radical Prostatectomy
    • Suprapubic Tube (SPT)
    • Urethral Catheters
    • Urodynamics
    • Varicocelectomy
  • Videos
  • Journal Club
    • Top 1000 Urology Journal Articles
    • Top Urology Journal Articles by Decade
    • Landmark Authors
    • Bladder Cancer Journal Club >
      • Landmark Papers
    • Reconstructive Journal Club >
      • Landmark Papers
    • Upper Tract Urothelial Carcinoma
URORESIDENT.COM
  • Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
          • Cysto, L RPG, L Stent
          • Cysto, R Stent w/o RPG
          • Cysto, R RPG, R Stent
        • Cysto, bladder biopsy
        • Cysto and TRUS Prostate Biopsy (OR)
        • Cysto Botox (F)
        • Individual parts of cystos
      • Prostate Biopsy >
        • Cysto and TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (office)
        • MRI Fusion TRUS Prostate Biopsy
      • Robot Left Radical Nephrectomy
      • Robot Right Radical Nephrectomy
      • Robot Radical Prostatectomy w/ PLND
      • TURBT (M)
      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
        • Left Proximal ESWL
        • Left Renal ESWL
        • Right Proximal ESWL
        • Right Renal ESWL
      • TURP
      • Vasectomy
    • Plans >
      • Erectile Dysfunction
      • NMIBC
      • Peyronie's Disease
      • Prostate Cancer
    • Medications >
      • Antibiotics >
        • Bactrim
        • Cephalosporins >
          • Keflex
        • Ciprofloxacin
        • Macrobid
        • Gentamicin
      • Medications and Dialysis
      • Anticoagulation and Antiplatelets
      • 5α-Reductase Inhibitors
      • PDE5i
      • Prostate Cancer Drugs >
        • Abiraterone
        • Androgen Receptor Blockers
        • Pembrolizumab
      • Anticholinergics & β-3 Agonists
      • Estrace
    • Patient Discussions >
      • Prostate Cancer
      • PSA Screening
      • Tobacco Cessation
    • Radiation Exposure
    • Medicolegal
    • Urology Jokes & Quotes
  • Subjects
    • Various Pathology >
      • Neurogenic Bladder/Spinal Cord Injury
      • CKD/ESRD
      • Erectile Dysfunction >
        • IPP
      • Female Urology
      • Hypogonadism
      • Imaging
      • Nocturia
      • Overactive Bladder
      • Trauma
      • Urine Retention
    • Urologic Malignancy >
      • Prostate Cancer >
        • Choosing Therapy
        • Imaging
        • Genomic Testing
        • Locally Advanced and BCR
        • Metastatic Prostate Cancer
        • ADT and Hormonal Therapy
        • Surgery
        • Radiation
        • Adjuvant & Salvage Therapy
        • Prostate Biopsy
        • Studies >
          • Landmark Studies
          • Research
      • Bladder Cancer >
        • MIBC
        • NMIBC >
          • Intravesical Therapy
        • Urine Markers
        • Chemotherapy
        • Metastatic Bladder Cancer
        • Immunotherapy
        • Cystectomy & PLND
        • Variant Histology
        • Trimodal Therapy
        • Post Cystectomy Care (ERAS)
        • Studies
      • Renal Cancer >
        • Work-up
        • Treatment
        • Surgery
        • Renal Cysts
        • Locally Advanced & Metastatic
        • RCC Surveillance
        • Calculators & Nomograms
        • Landmark Studies
        • Other Studies
      • Upper Tract UCC >
        • Laser Treatment >
          • Studies
        • UTUC Chemotherapy
        • Surgery
        • Landmark Studies
      • Testicular Cancer >
        • Evaluation
        • Treatment
        • Surveillance
        • Landmark Studies
      • Penile Cancer
      • Urethral Cancer
      • Adrenal Lesions
    • Stones >
      • Studies
      • Evaluation
      • Treatment (Non Surgical)
      • Surgical Treatment
    • BPH >
      • TURP
      • Urolift
      • Surgical Therapies
      • IPSS
    • Fertility >
      • Imaging and Lab Tests
      • Work-up
      • Surgery
      • Infertility in Spinal Cord Injury
      • Study guide
      • Interventions
      • Studies
    • Infection >
      • Fournier's Gangrene
      • Orchitis
      • UTI
      • Recurrent UTI
    • Incontinence >
      • Artificial Urethral Sphincter
      • Neuromodulation
      • Slings
      • Urethral Bulking
    • Pediatric Urology >
      • Pediatric Infections
      • Pediatric Surgery
      • Pediatric Tumors
      • Pediatric Trauma
    • Reconstruction >
      • Ureteral Stricture
      • Urethral Stricture
      • Studies
    • Other Random Studies >
      • Blood Transfusions
      • Fistula
      • Other studies/notes
  • Procedures
    • Cystectomy
    • Incisions
    • Endoscopic >
      • Cystoscopy
      • Ureteroscopy
      • Ureteral Stenting
    • Female Surgery >
      • Interstim & PTNS
      • Midurethral Sling
      • Sacrocolpopexy
    • Nephrectomy
    • PCNL
    • Prostate Biopsy
    • Radical Prostatectomy
    • Suprapubic Tube (SPT)
    • Urethral Catheters
    • Urodynamics
    • Varicocelectomy
  • Videos
  • Journal Club
    • Top 1000 Urology Journal Articles
    • Top Urology Journal Articles by Decade
    • Landmark Authors
    • Bladder Cancer Journal Club >
      • Landmark Papers
    • Reconstructive Journal Club >
      • Landmark Papers
    • Upper Tract Urothelial Carcinoma

Androgen Receptor Blockers

Enzalutamide
Can cause cardiovascular toxicities, accelerate bone loss, osteoporotic fractures, falls and cognitive impairment. (2-5).  The 2020 follow up at median 48mo (1) shows the following adverse events profile:
Picture
Sternberg, Cora N., et al. "Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer." New England Journal of Medicine (2020).
  1. Sternberg, Cora N., et al. "Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer." New England Journal of Medicine (2020).​
  2. Fizazi K., Tran N., Fein L., Matsubara N., Rodriguez-Antolin A., Alekseev B.Y., et al. Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer. N Engl J Med. 2017;377:352-360.
  3.  James N.D., de Bono J.S., Spears M.R., Clarke N.W., Mason M.D., Dearnaley D.P., et al. Abiraterone for prostate cancer not previously treated with hormone therapy. N Engl J Med. 2017;377:338-351.
  4. Davis I.D., Martin A.J., Stockler M.R., Begbie S., Chi K.N., Chowdhury S., et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med. 2019;381:121-131.
  5. Chi K.N., Agarwal N., Bjartell A., Chung B.H., Pereira de Santana Gomes A.J., Given R., et al. Apalutamide for metastatic, castration-sensitive prostate cancer. N Engl J Med. 2019;381:13-24.
Proudly powered by Weebly
  • Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
          • Cysto, L RPG, L Stent
          • Cysto, R Stent w/o RPG
          • Cysto, R RPG, R Stent
        • Cysto, bladder biopsy
        • Cysto and TRUS Prostate Biopsy (OR)
        • Cysto Botox (F)
        • Individual parts of cystos
      • Prostate Biopsy >
        • Cysto and TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (office)
        • MRI Fusion TRUS Prostate Biopsy
      • Robot Left Radical Nephrectomy
      • Robot Right Radical Nephrectomy
      • Robot Radical Prostatectomy w/ PLND
      • TURBT (M)
      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
        • Left Proximal ESWL
        • Left Renal ESWL
        • Right Proximal ESWL
        • Right Renal ESWL
      • TURP
      • Vasectomy
    • Plans >
      • Erectile Dysfunction
      • NMIBC
      • Peyronie's Disease
      • Prostate Cancer
    • Medications >
      • Antibiotics >
        • Bactrim
        • Cephalosporins >
          • Keflex
        • Ciprofloxacin
        • Macrobid
        • Gentamicin
      • Medications and Dialysis
      • Anticoagulation and Antiplatelets
      • 5α-Reductase Inhibitors
      • PDE5i
      • Prostate Cancer Drugs >
        • Abiraterone
        • Androgen Receptor Blockers
        • Pembrolizumab
      • Anticholinergics & β-3 Agonists
      • Estrace
    • Patient Discussions >
      • Prostate Cancer
      • PSA Screening
      • Tobacco Cessation
    • Radiation Exposure
    • Medicolegal
    • Urology Jokes & Quotes
  • Subjects
    • Various Pathology >
      • Neurogenic Bladder/Spinal Cord Injury
      • CKD/ESRD
      • Erectile Dysfunction >
        • IPP
      • Female Urology
      • Hypogonadism
      • Imaging
      • Nocturia
      • Overactive Bladder
      • Trauma
      • Urine Retention
    • Urologic Malignancy >
      • Prostate Cancer >
        • Choosing Therapy
        • Imaging
        • Genomic Testing
        • Locally Advanced and BCR
        • Metastatic Prostate Cancer
        • ADT and Hormonal Therapy
        • Surgery
        • Radiation
        • Adjuvant & Salvage Therapy
        • Prostate Biopsy
        • Studies >
          • Landmark Studies
          • Research
      • Bladder Cancer >
        • MIBC
        • NMIBC >
          • Intravesical Therapy
        • Urine Markers
        • Chemotherapy
        • Metastatic Bladder Cancer
        • Immunotherapy
        • Cystectomy & PLND
        • Variant Histology
        • Trimodal Therapy
        • Post Cystectomy Care (ERAS)
        • Studies
      • Renal Cancer >
        • Work-up
        • Treatment
        • Surgery
        • Renal Cysts
        • Locally Advanced & Metastatic
        • RCC Surveillance
        • Calculators & Nomograms
        • Landmark Studies
        • Other Studies
      • Upper Tract UCC >
        • Laser Treatment >
          • Studies
        • UTUC Chemotherapy
        • Surgery
        • Landmark Studies
      • Testicular Cancer >
        • Evaluation
        • Treatment
        • Surveillance
        • Landmark Studies
      • Penile Cancer
      • Urethral Cancer
      • Adrenal Lesions
    • Stones >
      • Studies
      • Evaluation
      • Treatment (Non Surgical)
      • Surgical Treatment
    • BPH >
      • TURP
      • Urolift
      • Surgical Therapies
      • IPSS
    • Fertility >
      • Imaging and Lab Tests
      • Work-up
      • Surgery
      • Infertility in Spinal Cord Injury
      • Study guide
      • Interventions
      • Studies
    • Infection >
      • Fournier's Gangrene
      • Orchitis
      • UTI
      • Recurrent UTI
    • Incontinence >
      • Artificial Urethral Sphincter
      • Neuromodulation
      • Slings
      • Urethral Bulking
    • Pediatric Urology >
      • Pediatric Infections
      • Pediatric Surgery
      • Pediatric Tumors
      • Pediatric Trauma
    • Reconstruction >
      • Ureteral Stricture
      • Urethral Stricture
      • Studies
    • Other Random Studies >
      • Blood Transfusions
      • Fistula
      • Other studies/notes
  • Procedures
    • Cystectomy
    • Incisions
    • Endoscopic >
      • Cystoscopy
      • Ureteroscopy
      • Ureteral Stenting
    • Female Surgery >
      • Interstim & PTNS
      • Midurethral Sling
      • Sacrocolpopexy
    • Nephrectomy
    • PCNL
    • Prostate Biopsy
    • Radical Prostatectomy
    • Suprapubic Tube (SPT)
    • Urethral Catheters
    • Urodynamics
    • Varicocelectomy
  • Videos
  • Journal Club
    • Top 1000 Urology Journal Articles
    • Top Urology Journal Articles by Decade
    • Landmark Authors
    • Bladder Cancer Journal Club >
      • Landmark Papers
    • Reconstructive Journal Club >
      • Landmark Papers
    • Upper Tract Urothelial Carcinoma