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  • Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
          • Cysto, L RPG, L Stent
          • Cysto, R Stent w/o RPG
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        • Cysto, bladder biopsy
        • Cysto and TRUS Prostate Biopsy (OR)
        • Cysto Botox (F)
        • Individual parts of cystos
      • Prostate Biopsy >
        • Cysto and TRUS Prostate Biopsy (OR)
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      • Robot Left Radical Nephrectomy
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      • Robot Radical Prostatectomy w/ PLND
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      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
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        • Ciprofloxacin
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Anticholinergics and β-3 Agonists

ANTICHOLINERGICS
GENERAL CONTRAINDICATIONS
History of urinary retention, gastric retention (gastroparesis), uncontrolled narrow-angle glaucoma and should be used carefully if reduced renal or hepatic dysfunction.

Solifenacin succinate

INDICATIONS

CONTRAINDICATIONS
Contraindicated in patients with urinary retention, gastric retention, ileus or small bowel obstruction, uncontrolled narrow-angle glaucoma and should be used carefully if reduced renal or hepatic dysfunction. >5mg solifenacin not recommended in patients with severe renal impairment, moderate hepatic impairment, or when administered with ketoconazole or other potent CYP3A4 inhibitors.

DOSAGE

SIDE EFFECTS
Urinary retention, delayed gastric emptying, constipation


STUDIES
One study found exposure to several types of strong anticholinergic drugs is associated with an increased risk of dementia (1)

β-3 Agonists
Mirabegron (Myrbetriq)
INDICATION

CONTRAINDICATION
Myrbetriq is not recommended for use in severe uncontrolled hypertensive patients (defined as systolic blood pressure ≥ 180mm Hg and/or diastolic blood pressure ≥ 110mm Hg). Caution with CYP2D6 inihbitors

DOSAGE

SIDE EFFECTS
Myrbetriq alone or in combination with solifenacin succinate can increase blood pressure.  Can cause urinary retention and is a CYP2D6 inhibitor.  CYP2D6 substrates such as metoprolol and desipramine are increased when co‐administered with Myrbetriq. One study found pilocarbine was safely used to treat dry mouth from anticholinergics.  (1)
  1. ​Coupland, Carol A. C., et al. “Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.” JAMA Internal Medicine, vol. 179, no. 8, 2019, pp. 1084–1093.
  2. Ko, Kwang Jin, et al. “Efficacy and Safety of Tolterodine and Pilocarpine in Patients with Overactive Bladder.” The Journal of Urology, vol. 202, no. 3, 2019, pp. 564–573.
​
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  • Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
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          • Cysto, R Stent w/o RPG
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        • Cysto, bladder biopsy
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        • Cysto Botox (F)
        • Individual parts of cystos
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        • Cysto and TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (office)
        • MRI Fusion TRUS Prostate Biopsy
      • Robot Left Radical Nephrectomy
      • Robot Right Radical Nephrectomy
      • Robot Radical Prostatectomy w/ PLND
      • TURBT (M)
      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
        • Left Proximal ESWL
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        • Right Proximal ESWL
        • Right Renal ESWL
      • TURP
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      • NMIBC
      • Peyronie's Disease
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    • Medications >
      • Antibiotics >
        • Bactrim
        • Cephalosporins >
          • Keflex
        • Ciprofloxacin
        • Macrobid
        • Gentamicin
      • Medications and Dialysis
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      • PDE5i
      • Prostate Cancer Drugs >
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        • Androgen Receptor Blockers
        • Pembrolizumab
      • Anticholinergics & β-3 Agonists
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      • Neurogenic Bladder/Spinal Cord Injury
      • CKD/ESRD
      • Erectile Dysfunction >
        • IPP
      • Female Urology
      • Hypogonadism
      • Imaging
      • Nocturia
      • Overactive Bladder
      • Trauma
      • Urine Retention
    • Urologic Malignancy >
      • Prostate Cancer >
        • Choosing Therapy
        • Imaging
        • Genomic Testing
        • Locally Advanced and BCR
        • Metastatic Prostate Cancer
        • ADT and Hormonal Therapy
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        • Radiation
        • Adjuvant & Salvage Therapy
        • Prostate Biopsy
        • Studies >
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        • Urine Markers
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        • Variant Histology
        • Trimodal Therapy
        • Post Cystectomy Care (ERAS)
        • Studies
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      • Artificial Urethral Sphincter
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      • Slings
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      • Other studies/notes
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    • Incisions
    • Endoscopic >
      • Cystoscopy
      • Ureteroscopy
      • Ureteral Stenting
    • Female Surgery >
      • Interstim & PTNS
      • Midurethral Sling
      • Sacrocolpopexy
    • Nephrectomy
    • PCNL
    • Prostate Biopsy
    • Radical Prostatectomy
    • Suprapubic Tube (SPT)
    • Urethral Catheters
    • Urodynamics
    • Varicocelectomy
  • Videos
  • Journal Club
    • Top 1000 Urology Journal Articles
    • Top Urology Journal Articles by Decade
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    • Bladder Cancer Journal Club >
      • Landmark Papers
    • Reconstructive Journal Club >
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