Androgen Receptor Blockers
Enzalutamide
Can cause cardiovascular toxicities, accelerate bone loss, osteoporotic fractures, falls and cognitive impairment. (2-5). The 2020 follow up at median 48mo (1) shows the following adverse events profile:
Can cause cardiovascular toxicities, accelerate bone loss, osteoporotic fractures, falls and cognitive impairment. (2-5). The 2020 follow up at median 48mo (1) shows the following adverse events profile:
Sternberg, Cora N., et al. "Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer." New England Journal of Medicine (2020).
- Sternberg, Cora N., et al. "Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer." New England Journal of Medicine (2020).
- Fizazi K., Tran N., Fein L., Matsubara N., Rodriguez-Antolin A., Alekseev B.Y., et al. Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer. N Engl J Med. 2017;377:352-360.
- James N.D., de Bono J.S., Spears M.R., Clarke N.W., Mason M.D., Dearnaley D.P., et al. Abiraterone for prostate cancer not previously treated with hormone therapy. N Engl J Med. 2017;377:338-351.
- Davis I.D., Martin A.J., Stockler M.R., Begbie S., Chi K.N., Chowdhury S., et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med. 2019;381:121-131.
- Chi K.N., Agarwal N., Bjartell A., Chung B.H., Pereira de Santana Gomes A.J., Given R., et al. Apalutamide for metastatic, castration-sensitive prostate cancer. N Engl J Med. 2019;381:13-24.