Renal Cell Carcinoma
5 year cancer specific survival for patients with stage I disease that is resected is greater than 90% .(1,2) After a radical nephrectomy, up to 5% have local (3,6,7,8) and 15% have distant metastatic recurrence at a median of 9 years. (3) In lymph node positive disease recurrence rates can be as high as 80%. (4) See SURGERY for more detailed and extensive local recurrence statistics.
Stage is the most important prognostic factor. 5 year cancer specific survival rates are:(5)
Stage is the most important prognostic factor. 5 year cancer specific survival rates are:(5)
- Stage I: 91-100%
- Stage II: 74-96%
- Stage III: 59-70%
- Stage IV: 16-32%
Aboutcancer.org
(1) >26k patients SEER data
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- Tsui, Ke-Hung, et al. "Prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 TNM staging criteria." The Journal of urology163.4 (2000): 1090-1095.
- Kim, Simon P., et al. "Outcomes and clinicopathologic variables associated with late recurrence after nephrectomy for localized renal cell carcinoma." Urology 78.5 (2011): 1101-1106.
- Babaian, Kara N., et al. "Preoperative predictors of pathological lymph node metastasis in patients with renal cell carcinoma undergoing retroperitoneal lymph node dissection." The Journal of urology 193.4 (2015): 1101-1107.
- Pantuck, Allan J., Amnon Zisman, and Arie S. Belldegrun. "The changing natural history of renal cell carcinoma." The Journal of urology 166.5 (2001): 1611-1623.
- Itano, Nancy B., et al. "Outcome of isolated renal cell carcinoma fossa recurrence after nephrectomy." The Journal of urology164.2 (2000): 322-325.
- Thomas, Arun Z., et al. "Surgical management of local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy." The Journal of urology 194.2 (2015): 316-322.
- Margulis, Vitaly, et al. "Predictors of oncological outcome after resection of locally recurrent renal cell carcinoma." The Journal of urology 181.5 (2009): 2044-2051.