Cephalosporins
Please see linked detailed information for the common cephalosporins we use:
cephalexin (Keflex)
cefixime (Suprax)
ceftriaxone (Rocephine)
The following chart has links to wikipedia pages for various medications:
cephalexin (Keflex)
cefixime (Suprax)
ceftriaxone (Rocephine)
The following chart has links to wikipedia pages for various medications:
1st Generation |
2nd Generation |
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Cefaclor (Ceclor) Cefuroxime (Ceftin) Antianaerobe activity: Cefoxitin Cefotetan (Cefotan) Cefoxitin (Mefoxin) |
Cefdinir (Omnicef) Cefixime (Suprax) Cefotaxime (Claforan) Cefpodoxime (Vantin) Ceftriaxone (Rocephin) Antipseudomonal: Ceftazidime (Fortaz) |
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MSSA Streptococci Grp A,B,C,G Strep Viridans S. pneumoniae H. influenzae E. coli Klebsiella pneumoniae Proteus mirabilis |
Same as 1st Generation Plus: β-lactamase positive H. influenzae Moraxella catarrhalis Neisseria meningitidis E. coli Klebsiella pneumoniae Proteus Oral anaerobes Cefoxitin & Cefotetan cover B. fragilis |
Same as 1st Generation Plus: Expanded gram-negative coverage Oral anaerobes S. aureus (OSSA) Strep pneumoniae Strep Grp A,B,C,G Strep viridans Gram negative rods N. gonorrhea All cover B. fragilis EXCEPT cefotaxime & ceftazidime P. aeruginosa - ceftazidine only |
Good gram-positive & gram-negative coverage Anti-Pseudomonal (including ceftazidime resistant isolates) Penetrates CSF Limited anaerobic coverage |
MRSA gram-positive bacteria, activity of later-generation cephalosporins with broad-spectrum activity against gram-negative bacteria |
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Holes in coverage: No CNS Penetration Cefuroxime does not have good coverage of gut anaerobes Cefoxitin or Cefotetan can be used as monotherapy of mild intra-abdominal & pelvic infections |
Holes in coverage: Poor gram-positive coverage E. faecium MRSA All cover OSSA EXCEPT ceftazidime Legionella / atypicals Listeria Acinetobacter Not all cover Pseudomonas |
lue |
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- Bartlett JG, Auwaerter PG, Pham PA (2010): The Johns Hopkins ABX Guide. Diagnosis and Treatment of Infectious Diseases. 2010 2nd Edition. Jones & Bartlett Publishers, Sudbury MA. (ISBN: 978-0-7637-8108-8)
- Deck DH, Winston LG (2012): Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics (Chapter 43). In: Basic and Clinical Pharmacology. 12e. Katzung BG, Masters SB, Trevor AJ (Editors). McGraw-Hill / Lange.
- rxlist.com (Cefazolin ®)