Fertility

FSH stimulates Sertoli cells to make sperm. Spermatogenesis takes 74 days to complete, they are made in seminiferous tubules where testosterone is required in the lumen. The little swimmers mature in the epididymis and are stored in the cauda. A fever can disrupt spermatogenesis for 3 months.

Risk factors for infertility in females are:

age>35
PCOS
PID
h/o tubal ligation
endometriosis

Risk factors for infertility in males are:

varicocele
ejaculation disorders
endocrine disorders
1. thyroid (hypo= ^ in prolactin
2. hypo/hypergonadotropic
prostatitis
DM
fever
mumps (after puberty)
liver disease
drugs - chemotherapy, cimetidine, colchicine, sulfasalazine, allopurinol, spironolactone, TCA's, dilantin. Aspirin and acetaminophen may negatively impact. Also Opiates

CF, kartagener's, Young syndrome, myotonic dystrophy, CBAVD,