PDE-5 Inhibitors
Sildenafil
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
TADALAFIL
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
VARDENAFIL
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
Tadalafil and vardenafil are more selective than sildenafil for PDE-6, and should not be associated with the related visual disturbances that occur in some patients on sildenafil. Vardenafil, has the highest in vitro potency of all available PDE-5 inhibitors, and tadalafil, has a prolonged half-life that may enable couples to have non-programmed sexual activity. One clinical study showed the efficacy and safety of using vardenafil in treating ED in hemodiaysis patients. (1) Sildenafil, tadalafil, avanafil, and vardenafil are metabolized by cytochrome P450 (CYP3A4), also metabolized by CYP3A4 are protease inhibitors, indinavir and ritonavir, ketoconazole, and macrolide antibiotics can increase serum levels of PDE5 inhibitors. (2)
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
TADALAFIL
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
VARDENAFIL
INDICATION
CONTRAINDICATION
DOSAGE
SIDE EFFECTS
Tadalafil and vardenafil are more selective than sildenafil for PDE-6, and should not be associated with the related visual disturbances that occur in some patients on sildenafil. Vardenafil, has the highest in vitro potency of all available PDE-5 inhibitors, and tadalafil, has a prolonged half-life that may enable couples to have non-programmed sexual activity. One clinical study showed the efficacy and safety of using vardenafil in treating ED in hemodiaysis patients. (1) Sildenafil, tadalafil, avanafil, and vardenafil are metabolized by cytochrome P450 (CYP3A4), also metabolized by CYP3A4 are protease inhibitors, indinavir and ritonavir, ketoconazole, and macrolide antibiotics can increase serum levels of PDE5 inhibitors. (2)
- El-Assmy, Ahmed. "Erectile dysfunction in hemodialysis: A systematic review." World journal of nephrology 1.6 (2012): 160.
- Pontari MA: Sexually transmitted diseases, in Wein AJ, Kavoussi LR, Partin AW, Peters CA (eds): CAMPBELL-WALSH UROLOGY, ed 11. Philadelphia, Elsevier, 2015, vol 1, chap 15, p 384.