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    • Dictations >
      • Circumcision
      • Cystoscopy >
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        • Cysto, +/- RPG +/- stent >
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          • Cysto, L stent w/o RPG
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PDE-5 Inhibitors

Sildenafil
INDICATION

CONTRAINDICATION

DOSAGE

SIDE EFFECTS

TADALAFIL
INDICATION


CONTRAINDICATION

DOSAGE

​SIDE EFFECTS

VARDENAFIL
INDICATION


CONTRAINDICATION

DOSAGE

​SIDE EFFECTS

​
Tadalafil and vardenafil are more selective than sildenafil for PDE-6, and should not be associated with the related visual disturbances that occur in some patients on sildenafil. Vardenafil, has the highest 
in vitro potency of all available PDE-5 inhibitors, and tadalafil, has a prolonged half-life that may enable couples to have non-programmed sexual activity. One clinical study showed the efficacy and safety of using vardenafil in treating ED in hemodiaysis patients. (1) Sildenafil, tadalafil, avanafil, and vardenafil are metabolized by cytochrome P450 (CYP3A4), also metabolized by CYP3A4 are protease inhibitors, indinavir and ritonavir, ketoconazole, and macrolide antibiotics can increase serum levels of PDE5 inhibitors. (2)
Picture
  1. El-Assmy, Ahmed. "Erectile dysfunction in hemodialysis: A systematic review." World journal of nephrology 1.6 (2012): 160.
  2. ​Pontari MA: Sexually transmitted diseases, in Wein AJ, Kavoussi LR, Partin AW, Peters CA (eds): CAMPBELL-WALSH UROLOGY, ed 11. Philadelphia, Elsevier, 2015, vol 1, chap 15, p 384.


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  • Home
  • Daily Tasks
    • Dictations >
      • Circumcision
      • Cystoscopy >
        • Cysto-OR
        • Cysto, +/- RPG +/- stent >
          • Cysto w/ b/l RPG
          • Cysto, L RPG
          • Cysto, R RPG
          • Cysto, L stent w/o RPG
          • Cysto, L RPG, L Stent
          • Cysto, R Stent w/o RPG
          • Cysto, R RPG, R Stent
        • Cysto, bladder biopsy
        • Cysto and TRUS Prostate Biopsy (OR)
        • Cysto Botox (F)
        • Individual parts of cystos
      • Prostate Biopsy >
        • Cysto and TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (OR)
        • TRUS Prostate Biopsy (office)
        • MRI Fusion TRUS Prostate Biopsy
      • Robot Left Radical Nephrectomy
      • Robot Right Radical Nephrectomy
      • Robot Radical Prostatectomy w/ PLND
      • TURBT (M)
      • Ureteroscopy >
        • L U-scope (flex), RPG, (F)
        • R U-scope (flex), RPG, (M)
        • L U-scope,semirigid laser, flex, RPG, stent removal, (F)
      • ESWL >
        • Left Proximal ESWL
        • Left Renal ESWL
        • Right Proximal ESWL
        • Right Renal ESWL
      • TURP
      • Vasectomy
    • Plans >
      • Erectile Dysfunction
      • NMIBC
      • Peyronie's Disease
      • Prostate Cancer
    • Medications >
      • Antibiotics >
        • Bactrim
        • Cephalosporins >
          • Keflex
        • Ciprofloxacin
        • Macrobid
        • Gentamicin
      • Medications and Dialysis
      • Anticoagulation and Antiplatelets
      • 5α-Reductase Inhibitors
      • PDE5i
      • Prostate Cancer Drugs >
        • Abiraterone
        • Androgen Receptor Blockers
        • Pembrolizumab
      • Anticholinergics & β-3 Agonists
      • Estrace
    • Patient Discussions >
      • Prostate Cancer
      • PSA Screening
      • Tobacco Cessation
    • Radiation Exposure
    • Medicolegal
    • Urology Jokes & Quotes
  • Subjects
    • Various Pathology >
      • Neurogenic Bladder/Spinal Cord Injury
      • CKD/ESRD
      • Erectile Dysfunction >
        • IPP
      • Female Urology
      • Hypogonadism
      • Imaging
      • Nocturia
      • Overactive Bladder
      • Trauma
      • Urine Retention
    • Urologic Malignancy >
      • Prostate Cancer >
        • Choosing Therapy
        • Imaging
        • Genomic Testing
        • Locally Advanced and BCR
        • Metastatic Prostate Cancer
        • ADT and Hormonal Therapy
        • Surgery
        • Radiation
        • Adjuvant & Salvage Therapy
        • Prostate Biopsy
        • Studies >
          • Landmark Studies
          • Research
      • Bladder Cancer >
        • MIBC
        • NMIBC >
          • Intravesical Therapy
        • Urine Markers
        • Chemotherapy
        • Metastatic Bladder Cancer
        • Immunotherapy
        • Cystectomy & PLND
        • Variant Histology
        • Trimodal Therapy
        • Post Cystectomy Care (ERAS)
        • Studies
      • Renal Cancer >
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        • Surgery
        • Renal Cysts
        • Locally Advanced & Metastatic
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        • Calculators & Nomograms
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          • Studies
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      • UTI
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      • Slings
      • Urethral Bulking
    • Pediatric Urology >
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      • Studies
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      • Blood Transfusions
      • Fistula
      • Other studies/notes
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    • Incisions
    • Endoscopic >
      • Cystoscopy
      • Ureteroscopy
      • Ureteral Stenting
    • Female Surgery >
      • Interstim & PTNS
      • Midurethral Sling
      • Sacrocolpopexy
    • Nephrectomy
    • PCNL
    • Prostate Biopsy
    • Radical Prostatectomy
    • Suprapubic Tube (SPT)
    • Urethral Catheters
    • Urodynamics
    • Varicocelectomy
  • Videos
  • Journal Club
    • Top 1000 Urology Journal Articles
    • Top Urology Journal Articles by Decade
    • Landmark Authors
    • Bladder Cancer Journal Club >
      • Landmark Papers
    • Reconstructive Journal Club >
      • Landmark Papers
    • Upper Tract Urothelial Carcinoma